KLHL13

Across TCGA patient cohorts, KLHL13 mutation is significantly associated with the total protein of many other genes, with 53 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KLHL13-associated genes across cancer lineages are Caspase-7-cleavedD198, mTOR_pS2448, and PCNA. Each is linked with KLHL13 in more than 3 cancer types. Because this analysis shows association rather than direction, both KLHL13-to-partner and partner-to-KLHL13 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by KLHL13-low versus KLHL13-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL13→partner) and Y-score (partner→KLHL13) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.376	+1.604	.027	.010	3	4
SKCM	mTOR_pS2448 →	-0.151	-1.765	.004	.010	3	3
UCEC	PCNA →	+0.214	+1.736	<.001	<.001	3	3
SKCM	BRD4 →	+0.246	+1.766	.037	.040	3	3
SKCM	Akt_pS473 →	-0.551	-1.857	<.001	<.001	3	2
SKCM	Smad4 →	+0.082	+1.519	.013	.029	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 53 associations by consensus.

Caspase-7-cleavedD198 by KLHL13 expression — UCEC

Explore this box plot interactively →