KLHL13

Across TCGA cell cohorts, KLHL13 mutation is significantly associated with the RNA expression of many other genes, with 284 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KLHL13-associated genes across cancer lineages are ANKRD54, TTLL12, and SAMM50. Each is linked with KLHL13 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLHL13-to-partner and partner-to-KLHL13 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ANKRD54 grouped by KLHL13-low versus KLHL13-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL13→partner) and Y-score (partner→KLHL13) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ANKRD54 →	+0.609	+3.588	<.001	<.001	3	1
LARGE_INTESTINE	TTLL12 →	+0.776	+2.451	.002	.009	3	1
LARGE_INTESTINE	SAMM50 →	+0.603	+3.502	<.001	.001	3	1
LARGE_INTESTINE	TRMU →	+0.615	+3.502	.001	.001	3	1
LARGE_INTESTINE	CHMP4B →	-0.560	-3.416	.006	.002	3	1
LARGE_INTESTINE	ZNF330 →	+0.515	+3.237	.002	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 284 associations by consensus.

ANKRD54 by KLHL13 expression — LARGE_INTESTINE

Explore this box plot interactively →