KLHL11

Across TCGA pan-cancer cohorts, KLHL11 Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated KLHL11 data layer compared with 29 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher KLHL11 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated KLHL11 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

HNSC, COAD, and CESC are the cancer types where KLHL11 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.156	0.710	.002	24	view →
COAD	OS	Median	III,IV	0.054	0.793	<.001	14	view →
CESC	OS	Median	All	0.097	0.590	.001	12	view →
LIHC	OS	Median	All	0.047	0.783	<.001	12	view →
SKCM	OS	Median	All	0.110	0.343	.002	12	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
UCEC	OS	Median	All	1.000	0.655	.020	6	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

KLHL11–HNSC (OS)

Open the HNSC breakdown →