KLHL11

Across TCGA pan-cancer cohorts, KLHL11 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated KLHL11 data layer compared with 29 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher KLHL11 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated KLHL11 expression acts as an unfavorable survival marker, although some lineages such as PDAC and HNSC show a favorable association.

PDAC, HNSC, and UCEC are the cancer types where KLHL11 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Quartile	III,IV	0.973	0.436	<.001	27	view →
HNSC	DFS	Tertile	II,III,IV	0.860	0.625	.015	9	view →
UCEC	OS	Tertile	All	1.000	0.888	.044	6	view →
LSCC	OS	Tertile	II,III,IV	0.931	0.663	.046	2	view →
CCRCC	DFS	Median	All	0.892	0.557	.024	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

KLHL11–PDAC (DFS)

Open the PDAC breakdown →