KLHL11

Across TCGA patient cohorts, KLHL11 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KLHL11-associated genes across cancer lineages are Notch1, eIF4E, and IGFBP2. Each is linked with KLHL11 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLHL11-to-partner and partner-to-KLHL11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by KLHL11-low versus KLHL11-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL11→partner) and Y-score (partner→KLHL11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.127	+1.415	.016	.046	3	2
UCEC	eIF4E →	+0.183	+2.335	.020	.018	3	1
UCEC	IGFBP2 →	-0.559	-1.765	.021	.014	3	1
UCEC	MEK1 →	+0.374	+2.807	.006	.003	3	1
UCEC	mTOR →	-0.168	-1.415	.005	.046	3	1
UCEC	p27_pT198 →	+0.114	+2.662	.004	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

Notch1 by KLHL11 expression — UCEC

Explore this box plot interactively →