KLHL11

Across TCGA cell cohorts, KLHL11 mutation is significantly associated with the RNA expression of many other genes, with 34 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible KLHL11-associated genes across cancer lineages are SLC32A1, IFNA14, and H2BW2. Each is linked with KLHL11 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLHL11-to-partner and partner-to-KLHL11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC32A1 grouped by KLHL11-low versus KLHL11-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL11→partner) and Y-score (partner→KLHL11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	SLC32A1 →	+0.016	+5.087	<.001	.004	3	2
SOFT_TISSUE	IFNA14 →	+0.032	+5.369	<.001	.004	3	1
BLOOD_Leukemia	H2BW2 →	+0.077	+4.556	<.001	<.001	3	1
BLOOD_Leukemia	PRMT8 →	+0.386	+3.824	<.001	.001	3	1
BLOOD_Leukemia	C6orf118 →	+0.037	+4.772	.001	<.001	3	1
BLOOD_Leukemia	MMP27 →	+0.013	+3.969	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

SLC32A1 by KLHL11 expression — URINARY_TRACT

Explore this box plot interactively →