KLHDC9

Across TCGA pan-cancer cohorts, KLHDC9 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of KLHDC9’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where KLHDC9 RNA is repressed in tumor relative to normal tissue. In most cancer types KLHDC9 is over-expressed in tumor, although a few such as KICH and KIRC show the opposite, repressed pattern.

KICH, KIRC, and THCA are the cancer types where KLHDC9 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KLHDC9 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	II,III,IV	−2.295	<.001	11	view →
KIRC	Male	All	−0.845	<.001	11	view →
THCA	Male	All	−0.521	<.001	8	view →
LUSC	Male	III,IV	−2.217	<.001	7	view →
LIHC	Male	II,III,IV	+1.427	<.001	6	view →
BRCA	All	III,IV	+1.243	<.001	6	view →
HNSC	All	All	−0.437	.029	4	view →
CHOL	All	All	+2.096	<.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

KLHDC9–KICH

Open the KICH breakdown →