KLHDC7B

Across TCGA patient cohorts, KLHDC7B mutation is significantly associated with the RNA expression of many other genes, with 1,249 significant associations in total. COAD shows the largest number of these associations.

The most reproducible KLHDC7B-associated genes across cancer lineages are RNU6-13P, RBFA, and MBD2. Each is linked with KLHDC7B in more than 2 cancer types. Because this analysis shows association rather than direction, both KLHDC7B-to-partner and partner-to-KLHDC7B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-13P grouped by KLHDC7B-low versus KLHDC7B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHDC7B→partner) and Y-score (partner→KLHDC7B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU6-13P →	+0.372	+2.800	<.001	<.001	3	3
COAD	RBFA →	+0.425	+2.700	.001	.006	3	3
COAD	MBD2 →	+0.475	+3.847	<.001	<.001	3	3
LIHC	NEK4P2 →	+0.144	+5.647	<.001	.004	3	2
LIHC	RN7SL754P →	+0.131	+5.447	<.001	.005	3	2
CESC	MIR4510 →	+0.159	+3.927	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,249 associations by consensus.

RNU6-13P by KLHDC7B expression — UCEC

Explore this box plot interactively →