KLHDC7B

Across TCGA patient cohorts, KLHDC7B mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KLHDC7B-associated genes across cancer lineages are EGFR_pY1068, INPP4B, and Lck. Each is linked with KLHDC7B in more than 1 cancer types. Because this analysis shows association rather than direction, both KLHDC7B-to-partner and partner-to-KLHDC7B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by KLHDC7B-low versus KLHDC7B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHDC7B→partner) and Y-score (partner→KLHDC7B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.365	-2.584	.001	.011	3	2
COAD	INPP4B →	-0.375	-3.000	.013	.034	3	2
COAD	Lck →	+0.539	+3.832	<.001	<.001	3	2
COAD	Caspase-7-cleavedD198 →	+1.195	+2.476	<.001	.009	3	2
UCEC	Annexin-1 →	+0.955	+3.479	<.001	.002	3	2
COAD	mTOR →	-0.178	-1.957	.033	.031	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

EGFR_pY1068 by KLHDC7B expression — UCEC

Explore this box plot interactively →