KLHDC7A

Across TCGA cell cohorts, KLHDC7A mutation is significantly associated with the RNA expression of many other genes, with 89 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KLHDC7A-associated genes across cancer lineages are HAO2, OR51B6, and OR1G1. Each is linked with KLHDC7A in more than 1 cancer types. Because this analysis shows association rather than direction, both KLHDC7A-to-partner and partner-to-KLHDC7A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HAO2 grouped by KLHDC7A-low versus KLHDC7A-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHDC7A→partner) and Y-score (partner→KLHDC7A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	HAO2 →	+0.067	+4.017	<.001	.007	3	2
OESOPHAGUS	OR51B6 →	+0.270	+4.017	<.001	.007	3	2
OESOPHAGUS	OR1G1 →	+0.046	+4.392	<.001	.003	3	2
LUNG_NSCLC_LUAD	OR51B2 →	+0.264	+4.179	.004	.001	3	2
LUNG_SCLC	OR10Q1 →	+0.653	+5.643	<.001	.002	3	2
OESOPHAGUS	RTP2 →	+0.017	+4.017	.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 89 associations by consensus.

HAO2 by KLHDC7A expression — OESOPHAGUS

Explore this box plot interactively →