KLHDC3

Across TCGA pan-cancer cohorts, KLHDC3 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated KLHDC3 data layer compared with 25 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher KLHDC3 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated KLHDC3 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and HNSC show a favorable association.

CCRCC, HNSC, and LUAD are the cancer types where KLHDC3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	III,IV	0.795	0.311	.007	39	view →
HNSC	OS	Quartile	II,III,IV	0.984	0.788	.002	35	view →
LUAD	OS	Median	All	0.612	1.000	.001	20	view →
LSCC	DFS	Quartile	All	0.849	0.557	.009	19	view →
UCEC	DFS	Quartile	II,III,IV	0.367	0.763	.041	4	view →
PDAC	DFS	Tertile	II,III,IV	0.662	0.339	.026	4	view →
GBM	OS	Median	All	0.414	0.637	.026	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

KLHDC3–CCRCC (DFS)

Open the CCRCC breakdown →