KLHDC3

Across TCGA pan-cancer cohorts, KLHDC3 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of KLHDC3’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where KLHDC3 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types KLHDC3 is over-expressed in tumor, although a few such as LUAD and HNSC show the opposite, repressed pattern.

LUAD, LSCC, and CCRCC are the cancer types where KLHDC3 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KLHDC3 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	All	−0.303	<.001	7	view →
LSCC	Male	All	+0.230	<.001	4	view →
CCRCC	Female	III,IV	+0.283	.023	3	view →
HNSC	Male	All	−0.190	.046	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

KLHDC3–LUAD

Open the LUAD breakdown →