KLHDC3

Across TCGA patient cohorts, KLHDC3 mutation is significantly associated with the immune_cell of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KLHDC3-associated genes across cancer lineages are CD8+ Tcm, MPP, and MSC. Each is linked with KLHDC3 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLHDC3-to-partner and partner-to-KLHDC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CD8+ Tcm grouped by KLHDC3-low versus KLHDC3-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHDC3→partner) and Y-score (partner→KLHDC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	CD8+ Tcm →	+0.067	+3.918	.045	.036	3	2
LIHC	MPP →	+0.023	+3.282	.048	.042	3	1
UCEC	MSC →	-0.238	-2.989	.014	.035	3	1
UCEC	aDC →	+0.068	+2.815	.047	.036	2	1
UCEC	Plasma cells →	-0.023	-2.542	.020	.011	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

CD8+ Tcm by KLHDC3 expression — CESC

Explore this box plot interactively →