KLHDC3

Across TCGA cell cohorts, KLHDC3 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible KLHDC3-associated genes across cancer lineages are PIK3C2G, TACR3, and PRND. Each is linked with KLHDC3 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLHDC3-to-partner and partner-to-KLHDC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PIK3C2G grouped by KLHDC3-low versus KLHDC3-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHDC3→partner) and Y-score (partner→KLHDC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PIK3C2G →	+0.017	+4.152	<.001	.009	3	1
BLOOD_Leukemia	TACR3 →	+0.035	+5.060	<.001	.001	3	1
BLOOD_Leukemia	PRND →	+0.011	+4.874	<.001	.002	3	1
BLOOD_Leukemia	MYPN →	+0.029	+4.152	<.001	.009	1	1
BLOOD_Leukemia	SOX1 →	+0.624	+4.149	<.001	.008	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

PIK3C2G by KLHDC3 expression — BLOOD_Leukemia

Explore this box plot interactively →