KLHDC2

Across TCGA patient cohorts, KLHDC2 protein abundance is significantly associated with the RNA expression of many other genes, with 9,493 significant associations in total. GBM shows the largest number of these associations.

The most reproducible KLHDC2-associated genes across cancer lineages are PTPN22, RNA5SP39, and CYTH4. Each is linked with KLHDC2 in more than 4 cancer types. Because this analysis shows association rather than direction, both KLHDC2-to-partner and partner-to-KLHDC2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, KLHDC2 versus PTPN22 in LSCC, with a Pearson correlation of -0.46.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHDC2→partner) and Y-score (partner→KLHDC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PTPN22 →	-0.749	-0.277	<.001	<.001	3	4
LUAD	RNA5SP39 →	-0.722	-0.217	.002	.004	3	4
GBM	CYTH4 →	-0.978	-0.372	<.001	<.001	3	4
HNSC	IL2RB →	-0.658	-0.311	.002	<.001	3	4
GBM	IL21R →	-0.814	-0.291	<.001	<.001	3	4
GBM	LILRB1 →	-0.675	-0.243	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,493 associations by consensus.

KLHDC2 vs PTPN22 — LSCC

Explore this scatter interactively →