KLHDC2

Across TCGA patient cohorts, KLHDC2 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KLHDC2-associated genes across cancer lineages are MAPK_pT202_Y204, MEK1_p_S217_S221, and Acetyl-a-Tubulin-Lys40. Each is linked with KLHDC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLHDC2-to-partner and partner-to-KLHDC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAPK_pT202_Y204 grouped by KLHDC2-low versus KLHDC2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHDC2→partner) and Y-score (partner→KLHDC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MAPK_pT202_Y204 →	-0.693	-3.169	.007	.020	3	1
UCEC	MEK1_p_S217_S221 →	-0.398	-3.169	.007	.019	3	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.729	+3.009	.008	.019	2	1
UCEC	NF-kB-p65_pS536 →	-0.655	-2.990	.008	.036	2	1
UCEC	PCNA →	+0.322	+3.169	.006	.020	2	1
UCEC	p62 Lck ligand →	+0.671	+3.169	<.001	.020	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

MAPK_pT202_Y204 by KLHDC2 expression — UCEC

Explore this box plot interactively →