KLHDC10

Across TCGA pan-cancer cohorts, KLHDC10 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated KLHDC10 data layer compared with 22 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher KLHDC10 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated KLHDC10 expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

HNSC, LSCC, and PDAC are the cancer types where KLHDC10 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.718	0.510	.014	11	view →
LSCC	OS	Tertile	III,IV	0.458	0.983	.008	8	view →
PDAC	DFS	Quartile	II,III,IV	0.644	0.960	.011	6	view →
LUAD	DFS	Median	III,IV	0.409	0.941	.010	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

KLHDC10–HNSC (DFS)

Open the HNSC breakdown →