KLHDC10

Across TCGA cell cohorts, KLHDC10 mutation is significantly associated with the drug of many other genes, with 20 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KLHDC10-associated genes across cancer lineages are Dactinomycin, AZD3759, and Sphingosine Kinase 1 Inhibitor II. Each is linked with KLHDC10 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLHDC10-to-partner and partner-to-KLHDC10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Dactinomycin grouped by KLHDC10-low versus KLHDC10-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHDC10→partner) and Y-score (partner→KLHDC10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Dactinomycin →	+0.506	+2.649	.031	.046	3	1
LARGE_INTESTINE	AZD3759 →	+0.491	+2.710	.046	.043	3	1
LARGE_INTESTINE	Sphingosine Kinase 1 Inhibitor II →	+0.237	+2.786	.037	.037	3	1
LARGE_INTESTINE	SGC-CBP30 →	+0.291	+2.649	.039	.046	2	1
LARGE_INTESTINE	50869 →	+0.453	+2.649	.032	.046	2	1
LARGE_INTESTINE	CCT007093 →	+0.317	+2.649	.033	.046	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

Dactinomycin by KLHDC10 expression — LARGE_INTESTINE

Explore this box plot interactively →