Across TCGA pan-cancer cohorts, KLHDC1 Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated KLHDC1 data layer compared with 24 for mass-spec protein.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher KLHDC1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated KLHDC1 expression acts as an unfavorable survival marker.

LUSC and ESCA are the cancer types where KLHDC1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	OS	Median	II,III,IV	0.147	0.743	.002	24	view →
ESCA	OS	Median	II,III,IV	0.321	0.685	.035	6	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: KLHDC1 tumor-vs-normal RNA expression · all KLHDC1 data types