Across TCGA pan-cancer cohorts, KLF8P1 RNA differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of KLF8P1’s most consistent transcriptional readouts.
The strongest signal is observed in lung adenocarcinoma (LUAD), where KLF8P1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types KLF8P1 is over-expressed in tumor.
LUAD are the cancer types where KLF8P1 tumor–normal differential expression is most reproducible.