KLF8

Across TCGA patient cohorts, KLF8 protein abundance is significantly associated with the RNA expression of many other genes, with 1,269 significant associations in total. GBM shows the largest number of these associations.

The most reproducible KLF8-associated genes across cancer lineages are KRT8P37, EIF3L, and APOBEC3H. Each is linked with KLF8 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLF8-to-partner and partner-to-KLF8 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, KLF8 versus KRT8P37 in LSCC, with a Pearson correlation of -0.67.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLF8→partner) and Y-score (partner→KLF8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	KRT8P37 →	-0.095	-0.567	.001	<.001	3	2
LSCC	EIF3L →	+0.528	+0.571	.005	.003	3	1
LSCC	APOBEC3H →	-0.605	-0.600	<.001	<.001	3	1
LSCC	CHCHD2 →	+0.981	+0.609	.003	.003	3	1
LSCC	RIC1 →	-0.552	-0.652	.006	<.001	3	1
LSCC	ELOVL3 →	+0.862	+0.520	.008	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,269 associations by consensus.

KLF8 vs KRT8P37 — LSCC

Explore this scatter interactively →