KLF8

Across TCGA patient cohorts, KLF8 mutation is significantly associated with the RNA expression of many other genes, with 2,269 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KLF8-associated genes across cancer lineages are RNU6-39P, RPARP-AS1, and RN7SKP263. Each is linked with KLF8 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLF8-to-partner and partner-to-KLF8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-39P grouped by KLF8-low versus KLF8-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLF8→partner) and Y-score (partner→KLF8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RNU6-39P →	+0.392	+3.684	<.001	.009	3	2
UCEC	RPARP-AS1 →	+0.398	+3.031	.002	<.001	3	2
CESC	RN7SKP263 →	+0.081	+4.569	<.001	.005	3	2
HNSC	RNU6-1075P →	+0.379	+6.608	<.001	.001	3	2
HNSC	RN7SKP126 →	+0.169	+5.736	<.001	.003	3	2
UCEC	BUB3 →	+0.379	+2.660	.002	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,269 associations by consensus.

RNU6-39P by KLF8 expression — LUSC

Explore this box plot interactively →