KLF8

Across TCGA patient cohorts, KLF8 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KLF8-associated genes across cancer lineages are p62 Lck ligand, C-Raf, and 14-3-3_beta. Each is linked with KLF8 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLF8-to-partner and partner-to-KLF8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by KLF8-low versus KLF8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLF8→partner) and Y-score (partner→KLF8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.278	+2.700	.015	.005	3	2
UCEC	C-Raf →	+0.129	+1.807	.010	.025	3	2
UCEC	14-3-3_beta →	-0.113	-1.986	.001	.003	3	1
UCEC	ACC_pS79 →	+0.263	+1.362	.031	.037	3	1
UCEC	JNK2 →	+0.166	+1.884	.017	.030	3	1
UCEC	Ku80 →	+0.239	+1.676	.004	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

p62 Lck ligand by KLF8 expression — UCEC

Explore this box plot interactively →