KLF8

Across TCGA cell cohorts, KLF8 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,493 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible KLF8-associated GO terms across cancer lineages are Intrinsic apoptotic signaling pathway, Regulation of mRNA processing, and Vesicle targeting, to, from or within Golgi. Each is linked with KLF8 in more than 9 cancer types. Because this analysis shows association rather than direction, both KLF8-to-partner and partner-to-KLF8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Intrinsic apoptotic signaling pathway grouped by KLF8-low versus KLF8-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (KLF8→partner) and Y-score (partner→KLF8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Intrinsic apoptotic signaling pathway →	+0.054	+1.220	<.001	.002	3	10
PANCREAS	Regulation of mRNA processing →	+0.071	+0.777	<.001	.009	3	9
LUNG_SCLC	Vesicle targeting, to, from or within Golgi →	+0.065	+1.177	.002	.001	3	9
OVARY	Negative regulation of mRNA metabolic process →	+0.070	+1.481	<.001	<.001	3	9
OVARY	Golgi vesicle transport →	+0.060	+1.617	<.001	<.001	3	9
BLOOD_Leukemia	Regulation of intrinsic apoptotic signaling pathway →	+0.061	+1.045	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,493 associations by consensus.

Intrinsic apoptotic signaling pathway by KLF8 expression — OVARY

Explore this box plot interactively →