KLF8

Across TCGA cell cohorts, KLF8 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible KLF8-associated genes across cancer lineages are SPATA19, OR6B3, and LCE1C. Each is linked with KLF8 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLF8-to-partner and partner-to-KLF8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPATA19 grouped by KLF8-low versus KLF8-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLF8→partner) and Y-score (partner→KLF8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SPATA19 →	+0.030	+6.569	<.001	<.001	3	1
BLOOD_Leukemia	OR6B3 →	+0.022	+5.539	<.001	.003	3	1
BLOOD_Leukemia	LCE1C →	+0.432	+4.922	.002	.009	3	1
BLOOD_Leukemia	MTRNR2L10 →	+0.028	+4.922	<.001	.009	3	1
BLOOD_Leukemia	SLC5A8 →	+0.182	+5.201	<.001	.006	3	1
BLOOD_Leukemia	OR10A6 →	+0.044	+5.201	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

SPATA19 by KLF8 expression — BLOOD_Leukemia

Explore this box plot interactively →