KLF6

Across TCGA pan-cancer cohorts, KLF6 mass-spec protein differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of KLF6’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where KLF6 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types KLF6 is over-expressed in tumor, although a few such as LSCC and PDAC show the opposite, repressed pattern.

CCRCC, LSCC, and PDAC are the cancer types where KLF6 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KLF6 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Male	All	+0.265	.010	3	view →
LSCC	Female	All	−0.600	.012	2	view →
PDAC	All	All	−1.124	.016	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

KLF6–CCRCC

Open the CCRCC breakdown →