KLF4

Across TCGA pan-cancer cohorts, KLF4 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated KLF4 data layer compared with 23 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher KLF4 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated KLF4 expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCEC show a favorable association.

HNSC, UCEC, and LUAD are the cancer types where KLF4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	IV	0.969	0.724	.007	22	view →
UCEC	OS	Quartile	III,IV	1.000	0.140	.024	12	view →
LUAD	OS	Quartile	II,III,IV	1.000	0.325	.049	2	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

KLF4–HNSC (OS)

Open the HNSC breakdown →