KLF4

Across TCGA patient cohorts, KLF4 RNA expression is significantly associated with the protein abundance of many other proteins, with 14,597 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible KLF4-associated proteins across cancer lineages are KLF4_T316, HSPB1_S15, and CAVIN2. Each is linked with KLF4 in more than 6 cancer types. Because this analysis shows association rather than direction, both KLF4-to-partner and partner-to-KLF4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, KLF4 versus KLF4_T316 in LSCC, with a Pearson correlation of 0.63.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (KLF4→partner) and Y-score (partner→KLF4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	KLF4_T316 →	+0.662	+1.053	<.001	<.001	3	7
CCRCC	HSPB1_S15 →	+1.042	+0.611	.002	.007	3	6
BRCA	CAVIN2 →	+0.868	+1.233	<.001	<.001	3	5
GBM	F5 →	+0.771	+0.938	<.001	<.001	3	5
CCRCC	BIN3 →	+0.355	+0.641	<.001	.004	3	5
LSCC	AHNAK_T490 →	+0.644	+0.901	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,597 associations by consensus.

KLF4 vs KLF4_T316 — LSCC

Explore this scatter interactively →