KLF4

Across TCGA patient cohorts, KLF4 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KLF4-associated genes across cancer lineages are eEF2, EGFR_pY1068, and MSH6. Each is linked with KLF4 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLF4-to-partner and partner-to-KLF4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by KLF4-low versus KLF4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLF4→partner) and Y-score (partner→KLF4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.424	+2.415	<.001	.003	3	2
UCEC	EGFR_pY1068 →	-0.227	-1.662	.010	.011	3	2
UCEC	MSH6 →	-0.355	-2.584	.002	.010	3	2
UCEC	Myosin-IIa_pS1943 →	+0.156	+1.676	.032	.007	3	2
UCEC	Notch1 →	+0.199	+2.713	<.001	.003	3	2
UCEC	PCNA →	+0.249	+2.000	.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

eEF2 by KLF4 expression — UCEC

Explore this box plot interactively →