KLF4

Across TCGA cell cohorts, KLF4 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,498 significant associations in total. BONE shows the largest number of these associations.

The most reproducible KLF4-associated GO terms across cancer lineages are Mesodermal cell fate commitment, Negative regulation of leukocyte adhesion to vascular endothelial cell, and Response to endothelin. Each is linked with KLF4 in more than 16 cancer types. Because this analysis shows association rather than direction, both KLF4-to-partner and partner-to-KLF4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Mesodermal cell fate commitment grouped by KLF4-low versus KLF4-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (KLF4→partner) and Y-score (partner→KLF4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Mesodermal cell fate commitment →	+1.565	+2.127	<.001	<.001	3	17
LUNG_SCLC	Negative regulation of leukocyte adhesion to vascular endothelial cell →	+1.432	+2.069	<.001	<.001	3	16
STOMACH	Response to endothelin →	+0.221	+2.868	<.001	<.001	3	15
OESOPHAGUS	Cellular response to endothelin →	+0.185	+1.999	<.001	<.001	3	15
LIVER	Negative regulation of chemokine (C-X-C motif) ligand 2 production →	+1.000	+2.048	<.001	<.001	3	14
LIVER	Regulation of leukocyte adhesion to arterial endothelial cell →	+1.333	+2.702	.004	.002	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,498 associations by consensus.

Mesodermal cell fate commitment by KLF4 expression — SKIN

Explore this box plot interactively →