KLF2

Across TCGA cell cohorts, KLF2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,745 significant associations in total. BONE shows the largest number of these associations.

The most reproducible KLF2-associated GO terms across cancer lineages are Dephosphorylation, Regulation of Ras protein signal transduction, and Glycine catabolic process. Each is linked with KLF2 in more than 10 cancer types. Because this analysis shows association rather than direction, both KLF2-to-partner and partner-to-KLF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Dephosphorylation grouped by KLF2-low versus KLF2-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (KLF2→partner) and Y-score (partner→KLF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Dephosphorylation →	+0.043	+2.564	.001	<.001	3	10
SKIN	Regulation of Ras protein signal transduction →	+0.097	+1.137	<.001	.002	2	11
SOFT_TISSUE	Glycine catabolic process →	-0.204	-1.257	.002	.005	3	10
LARGE_INTESTINE	Adult heart development →	+1.562	+1.518	<.001	<.001	3	10
SOFT_TISSUE	Glycine decarboxylation via glycine cleavage system →	-0.204	-1.257	.002	.005	3	10
UPPER_AERODIGESTIVE_TRACT	Positive regulation of retinoic acid receptor signaling pathway →	-0.170	-0.658	<.001	.004	2	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,745 associations by consensus.

Dephosphorylation by KLF2 expression — BONE

Explore this box plot interactively →