KLF2

Across TCGA cell cohorts, KLF2 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible KLF2-associated genes across cancer lineages are ADAM2, TAS2R7, and METTL11B. Each is linked with KLF2 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLF2-to-partner and partner-to-KLF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ADAM2 grouped by KLF2-low versus KLF2-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLF2→partner) and Y-score (partner→KLF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	ADAM2 →	+0.198	+4.714	<.001	.002	3	1
BLOOD_Lymphoma	TAS2R7 →	+0.021	+4.643	<.001	.005	3	1
BLOOD_Lymphoma	METTL11B →	+0.164	+4.191	<.001	.007	3	1
BLOOD_Leukemia	IQCF5 →	+0.124	+5.201	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

ADAM2 by KLF2 expression — BLOOD_Lymphoma

Explore this box plot interactively →