KLF16

Across TCGA pan-cancer cohorts, KLF16 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated KLF16 data layer compared with 23 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher KLF16 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated KLF16 expression acts as an unfavorable survival marker, although some lineages such as LSCC show a favorable association.

CCRCC, LSCC, and LUAD are the cancer types where KLF16 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Quartile	II,III,IV	0.329	0.902	.007	20	view →
LSCC	OS	Median	II,III,IV	0.904	0.626	.013	8	view →
LUAD	DFS	Median	All	0.401	0.786	.004	8	view →
COAD	DFS	Median	II,III,IV	0.821	1.000	.049	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

KLF16–CCRCC (DFS)

Open the CCRCC breakdown →