KLF13

Across TCGA patient cohorts, KLF13 mutation is significantly associated with the total protein of many other genes, with 50 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KLF13-associated genes across cancer lineages are eIF4E, 14-3-3_beta, and eEF2. Each is linked with KLF13 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLF13-to-partner and partner-to-KLF13 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by KLF13-low versus KLF13-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLF13→partner) and Y-score (partner→KLF13) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.204	+3.183	.013	.009	3	2
UCEC	14-3-3_beta →	-0.121	-2.432	.002	.018	3	1
UCEC	eEF2 →	+0.352	+1.874	.012	.049	3	1
UCEC	EGFR_pY1068 →	-0.350	-3.700	<.001	.001	3	1
UCEC	A-Raf_pS299 →	-0.217	-4.000	<.001	<.001	3	1
UCEC	ERK2 →	+0.219	+2.502	.003	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 50 associations by consensus.

eIF4E by KLF13 expression — UCEC

Explore this box plot interactively →