KLF12

Across TCGA pan-cancer cohorts, KLF12 mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated KLF12 data layer compared with 26 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher KLF12 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated KLF12 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

CCRCC and UCEC are the cancer types where KLF12 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	All	0.079	0.970	.008	6	view →
UCEC	DFS	Quartile	All	0.905	0.568	.042	4	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

KLF12–CCRCC (OS)

Open the CCRCC breakdown →