KLF12

Across TCGA patient cohorts, KLF12 mutation is significantly associated with the RNA expression of many other genes, with 5,598 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KLF12-associated genes across cancer lineages are CWC25, TMEM269, and TADA2A. Each is linked with KLF12 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLF12-to-partner and partner-to-KLF12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CWC25 grouped by KLF12-low versus KLF12-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLF12→partner) and Y-score (partner→KLF12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CWC25 →	+0.384	+2.161	<.001	<.001	3	2
UCEC	TMEM269 →	+0.177	+1.572	<.001	<.001	3	2
UCEC	TADA2A →	+0.315	+2.364	<.001	<.001	3	2
UCEC	RNA5SP412 →	+0.412	+1.426	<.001	.005	3	2
UCEC	RNVU1-28 →	+0.476	+1.298	<.001	.002	3	2
UCEC	LIN7C →	+0.630	+1.938	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,598 associations by consensus.

CWC25 by KLF12 expression — UCEC

Explore this box plot interactively →