KLF12

Across TCGA patient cohorts, KLF12 mutation is significantly associated with the total protein of many other genes, with 52 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KLF12-associated genes across cancer lineages are eEF2, eIF4E, and ERK2. Each is linked with KLF12 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLF12-to-partner and partner-to-KLF12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by KLF12-low versus KLF12-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLF12→partner) and Y-score (partner→KLF12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.309	+1.906	.002	.014	3	2
UCEC	eIF4E →	+0.159	+1.688	.009	.001	3	2
UCEC	ERK2 →	+0.177	+1.485	.001	.003	3	2
UCEC	MEK1 →	+0.406	+1.906	<.001	<.001	3	2
UCEC	mTOR_pS2448 →	-0.122	-2.074	.005	.004	3	2
UCEC	STAT3_pY705 →	-0.354	-1.874	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 52 associations by consensus.

eEF2 by KLF12 expression — UCEC

Explore this box plot interactively →