KLF12

Across TCGA cell cohorts, KLF12 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,636 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible KLF12-associated GO terms across cancer lineages are Positive regulation of double-strand break repair, Regulation of double-strand break repair, and Regulation of microtubule cytoskeleton organization. Each is linked with KLF12 in more than 12 cancer types. Because this analysis shows association rather than direction, both KLF12-to-partner and partner-to-KLF12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of double-strand break repair grouped by KLF12-low versus KLF12-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (KLF12→partner) and Y-score (partner→KLF12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Positive regulation of double-strand break repair →	+0.073	+1.249	<.001	<.001	3	13
LUNG_SCLC	Regulation of double-strand break repair →	+0.065	+1.124	<.001	.002	3	12
LUNG_SCLC	Regulation of microtubule cytoskeleton organization →	+0.082	+1.281	<.001	<.001	3	12
BREAST	Regulation of G1/S transition of mitotic cell cycle →	+0.062	+0.812	<.001	<.001	3	12
LUNG_SCLC	Positive regulation of DNA repair →	+0.058	+1.253	<.001	<.001	3	12
OESOPHAGUS	Positive regulation of chromosome organization →	+0.071	+0.793	.009	.009	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,636 associations by consensus.

Positive regulation of double-strand break repair by KLF12 expression — LUNG_SCLC

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