KLF11

Across TCGA cell cohorts, KLF11 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,815 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible KLF11-associated GO terms across cancer lineages are Regulation of macroautophagy, Regulation of autophagosome assembly, and Regulation of vacuole organization. Each is linked with KLF11 in more than 9 cancer types. Because this analysis shows association rather than direction, both KLF11-to-partner and partner-to-KLF11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of macroautophagy grouped by KLF11-low versus KLF11-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (KLF11→partner) and Y-score (partner→KLF11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Regulation of macroautophagy →	+0.062	+1.030	.002	.003	3	10
LUNG_NSCLC_LUAD	Regulation of autophagosome assembly →	+0.065	+0.785	<.001	<.001	3	10
LUNG_NSCLC_LUAD	Regulation of vacuole organization →	+0.056	+0.761	<.001	<.001	3	10
BLOOD_Myeloma	Autophagosome organization →	+0.052	+1.725	.001	<.001	3	8
LIVER	Cellular response to nutrient levels →	+0.053	+0.980	<.001	<.001	3	8
SOFT_TISSUE	Positive regulation of autophagy →	+0.032	+0.867	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,815 associations by consensus.

Regulation of macroautophagy by KLF11 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →