KLF11

Across TCGA cell cohorts, KLF11 mutation is significantly associated with the RNA expression of many other genes, with 19 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KLF11-associated genes across cancer lineages are SPATA48, OR4N4, and KRTAP5-6. Each is linked with KLF11 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLF11-to-partner and partner-to-KLF11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPATA48 grouped by KLF11-low versus KLF11-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLF11→partner) and Y-score (partner→KLF11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	SPATA48 →	+0.012	+4.977	<.001	.007	3	2
BLOOD_Leukemia	OR4N4 →	+0.021	+4.289	.005	<.001	3	1
BLOOD_Leukemia	KRTAP5-6 →	+0.232	+4.289	<.001	<.001	3	1
SKIN	OR5T3 →	+0.020	+6.022	<.001	.001	3	1
OVARY	SEL1L2 →	+0.043	+3.938	<.001	.005	3	1
LARGE_INTESTINE	MS4A4A →	+0.176	+3.000	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

SPATA48 by KLF11 expression — SKIN

Explore this box plot interactively →