KLF10

Across TCGA patient cohorts, KLF10 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KLF10-associated genes across cancer lineages are Notch1, Cyclin-B1, and EGFR_pY1068. Each is linked with KLF10 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLF10-to-partner and partner-to-KLF10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by KLF10-low versus KLF10-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLF10→partner) and Y-score (partner→KLF10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.148	+3.013	.019	.018	3	2
UCEC	Cyclin-B1 →	+0.810	+3.807	.001	<.001	3	2
UCEC	EGFR_pY1068 →	-0.252	-2.000	.025	.032	3	1
UCEC	FoxM1 →	+0.244	+2.000	.036	.032	3	1
UCEC	INPP4B →	-0.384	-3.169	.008	.018	3	1
UCEC	p62 Lck ligand →	+0.314	+2.000	.032	.032	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

Notch1 by KLF10 expression — UCEC

Explore this box plot interactively →