KLC3

Across TCGA pan-cancer cohorts, KLC3 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated KLC3 data layer compared with 27 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher KLC3 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated KLC3 expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCEC show a favorable association.

HNSC, CCRCC, and UCEC are the cancer types where KLC3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Quartile	All	0.932	0.739	.020	29	view →
CCRCC	OS	Quartile	II,III,IV	0.535	0.865	.002	12	view →
UCEC	DFS	Median	All	1.000	0.926	.021	6	view →
PDAC	DFS	Median	All	0.226	0.462	.003	3	view →
LSCC	OS	Tertile	II,III,IV	0.816	0.960	.043	1	view →
LUAD	OS	Quartile	All	0.610	0.880	.039	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

KLC3–HNSC (OS)

Open the HNSC breakdown →