KLC3

Across TCGA patient cohorts, KLC3 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KLC3-associated genes across cancer lineages are Annexin-1, VEGFR2, and 4E-BP1. Each is linked with KLC3 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLC3-to-partner and partner-to-KLC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Annexin-1 grouped by KLC3-low versus KLC3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLC3→partner) and Y-score (partner→KLC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Annexin-1 →	+0.611	+2.000	.010	.032	3	2
UCEC	VEGFR2 →	+0.407	+2.013	.002	.018	3	2
UCEC	4E-BP1 →	+0.385	+2.700	.001	.006	3	2
UCEC	eIF4E →	+0.232	+3.013	.014	.018	3	1
UCEC	A-Raf_pS299 →	-0.184	-2.000	<.001	.032	3	1
UCEC	Myosin-IIa_pS1943 →	+0.202	+2.713	.029	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

Annexin-1 by KLC3 expression — UCEC

Explore this box plot interactively →