KLC3

Across TCGA cell cohorts, KLC3 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible KLC3-associated genes across cancer lineages are OR1L3, PRAMEF17, and OR52L1. Each is linked with KLC3 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLC3-to-partner and partner-to-KLC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR1L3 grouped by KLC3-low versus KLC3-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLC3→partner) and Y-score (partner→KLC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	OR1L3 →	+0.029	+5.415	<.001	.004	3	1
SKIN	PRAMEF17 →	+0.016	+6.022	<.001	.001	3	1
OVARY	OR52L1 →	+0.118	+5.196	<.001	.005	3	1
OVARY	CT45A6 →	+0.072	+5.196	<.001	.005	3	1
BLOOD_Leukemia	DMRTC2 →	+0.036	+4.539	<.001	.007	3	1
BLOOD_Leukemia	LYZL4 →	+0.080	+4.152	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

OR1L3 by KLC3 expression — SKIN

Explore this box plot interactively →