KLC2

Across TCGA pan-cancer cohorts, KLC2 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated KLC2 data layer compared with 26 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher KLC2 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated KLC2 expression acts as an unfavorable survival marker, although some lineages such as UCEC and LSCC show a favorable association.

UCEC, CCRCC, and LUAD are the cancer types where KLC2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Quartile	All	1.000	0.775	.002	58	view →
CCRCC	OS	Tertile	All	0.720	0.954	.004	15	view →
LUAD	DFS	Median	All	0.523	0.767	.015	13	view →
HNSC	DFS	Tertile	All	0.317	0.715	.047	4	view →
GBM	OS	Quartile	All	0.229	0.634	.026	2	view →
LSCC	OS	Quartile	All	1.000	0.669	.029	1	view →
PDAC	OS	Median	All	0.803	0.913	.034	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

KLC2–UCEC (DFS)

Open the UCEC breakdown →