KLC2

Across TCGA patient cohorts, KLC2 RNA expression is significantly associated with the protein abundance of many other proteins, with 15,000 significant associations in total. GBM shows the largest number of these associations.

The most reproducible KLC2-associated proteins across cancer lineages are FMNL1_S184, KLC2_S151, and KLC2_S582. Each is linked with KLC2 in more than 4 cancer types. Because this analysis shows association rather than direction, both KLC2-to-partner and partner-to-KLC2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, KLC2 versus FMNL1_S184 in LSCC, with a Pearson correlation of -0.35.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (KLC2→partner) and Y-score (partner→KLC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	FMNL1_S184 →	-0.859	-0.521	.001	<.001	3	5
BRCA	KLC2_S151 →	+0.673	+0.698	<.001	<.001	3	5
BRCA	KLC2_S582 →	+0.488	+0.628	<.001	<.001	3	5
LUAD	MAST3_S747 →	-0.663	-0.406	.002	<.001	3	5
GBM	WASF2 →	-0.201	-0.444	.007	<.001	3	4
PDAC	TBC1D10A_S409 →	-0.860	-0.266	.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,000 associations by consensus.

KLC2 vs FMNL1_S184 — LSCC

Explore this scatter interactively →