KLC2

Across TCGA patient cohorts, KLC2 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KLC2-associated genes across cancer lineages are eIF4E, ASNS, and Caspase-7-cleavedD198. Each is linked with KLC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLC2-to-partner and partner-to-KLC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by KLC2-low versus KLC2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLC2→partner) and Y-score (partner→KLC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.187	+2.000	.024	.010	3	2
COAD	ASNS →	+0.635	+3.169	<.001	.017	3	2
COAD	Caspase-7-cleavedD198 →	+1.335	+3.338	<.001	.004	3	2
COAD	Caveolin-1 →	-0.845	-3.459	.004	.005	3	2
UCEC	Cyclin-B1 →	+0.698	+2.502	.001	.002	3	2
UCEC	mTOR_pS2448 →	-0.123	-2.308	.036	.033	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

eIF4E by KLC2 expression — UCEC

Explore this box plot interactively →