KLC2

Across TCGA cell cohorts, KLC2 mutation is significantly associated with the RNA expression of many other genes, with 96 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible KLC2-associated genes across cancer lineages are OR10R2, WDR87, and MS4A3. Each is linked with KLC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLC2-to-partner and partner-to-KLC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10R2 grouped by KLC2-low versus KLC2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLC2→partner) and Y-score (partner→KLC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OR10R2 →	+0.021	+3.562	<.001	.002	3	2
UPPER_AERODIGESTIVE_TRACT	WDR87 →	+0.023	+4.209	<.001	.006	3	1
LARGE_INTESTINE	MS4A3 →	+0.081	+3.584	.001	.003	3	1
LARGE_INTESTINE	IL20 →	+0.210	+3.984	<.001	.001	3	1
LARGE_INTESTINE	TBC1D21 →	+0.008	+3.700	<.001	.009	3	1
LARGE_INTESTINE	OR4F4 →	+0.015	+3.103	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 96 associations by consensus.

OR10R2 by KLC2 expression — LARGE_INTESTINE

Explore this box plot interactively →