KL

Across TCGA patient cohorts, KL mutation is significantly associated with the RNA expression of many other genes, with 3,998 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KL-associated genes across cancer lineages are NUDT2, PPP2R2D, and RN7SL134P. Each is linked with KL in more than 3 cancer types. Because this analysis shows association rather than direction, both KL-to-partner and partner-to-KL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NUDT2 grouped by KL-low versus KL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KL→partner) and Y-score (partner→KL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NUDT2 →	+0.490	+1.880	<.001	.004	3	4
UCEC	PPP2R2D →	+0.242	+2.233	.001	.001	3	4
CESC	RN7SL134P →	+0.134	+3.704	<.001	.001	3	3
UCEC	ZFYVE19 →	+0.423	+1.964	<.001	<.001	3	3
SKCM	CCDC8 →	-0.746	-1.575	.005	.002	3	3
UCEC	CDCA2 →	+0.689	+2.684	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,998 associations by consensus.

NUDT2 by KL expression — UCEC

Explore this box plot interactively →