KL

Across TCGA patient cohorts, KL mutation is significantly associated with the total protein of many other genes, with 54 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KL-associated genes across cancer lineages are ATM, eIF4G, and mTOR_pS2448. Each is linked with KL in more than 2 cancer types. Because this analysis shows association rather than direction, both KL-to-partner and partner-to-KL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by KL-low versus KL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KL→partner) and Y-score (partner→KL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.541	-2.321	<.001	<.001	3	3
UCEC	eIF4G →	+0.258	+2.700	.006	.005	3	2
UCEC	mTOR_pS2448 →	-0.122	-1.745	.007	.013	3	2
UCEC	Rad50 →	-0.167	-2.571	.024	.010	3	2
UCEC	Annexin-1 →	+0.569	+3.107	<.001	<.001	3	2
UCEC	Shc_pY317 →	-0.123	-1.584	.008	.017	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

ATM by KL expression — UCEC

Explore this box plot interactively →